A Novel Magnetite C18/Paracetamol/Alginate Bead as Adsorbent for Simultaneous Extraction and Determination of Synthetic Antioxidants and Bisphenol A in Water Samples

Abstract

This thesis aims to develop a novel magnetite C18/paracetamol//alginate bead-based on magnetic solid phase extraction for simultaneous extraction and determination of synthetic antioxidants, i.e. butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), and bisphenol A (BPA) from water samples coupled with gas chromatography-flame ionization detection. A magnetic composite bead was composed of magnetite, carbon 18 and paracetamol incorporated with alginate (mC18/Pa/Alg). The morphology and composition of the bead were examined by field emission scanning electron microscope, energy-dispersive X-ray spectrometry, X-ray diffraction spectroscopy, Fourier transform infrared spectroscopy, and Brunauer-Emmett-Teller technique. The adsorption of synthetic antioxidants and BPA is attributed to hydrogen bonding, ?-? stacking, and hydrophobic interaction. The best extraction conditions were of 0.8% sodium alginate, 0.3 g of adsorbent, solution pH at 7 and desorption time of 10 min, and methanol as desorption solvent. Under the optimum condition, the linear calibration plot ranged from 0.015 and 1.00 ?g mL-1 with a limit of detection ranging of 6.86-9.66 ng mL-1. The developed method was successfully applied in water samples with acceptable recoveries (80.28-100.09%) and precisions (RSDs) of 0.46-4.32%.??????????????????????????????????????????????????????????????? ??????? 18/???????????/?????????????????????????????????????????????????????????????????????????????????????????????????? ??? ??????????????????????? ???????????????????????????????????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????? ??????? 18 ??? ????????????????????????? ???????????????????????????????????????????????????????????????????????????????????????????????? ??????????????????????????????????????? ???????????????????????????????? ???????????????????????????????????????? ??? ?????????????? ???????????????????? ?????????????????????????????????????????????????????????????????????????????????????????????? ?????-?? ???????????????? ??????????????????????? ??? ??????????????????????????????????? 0.8 ???????????????? 0.3 ???? ??????????????????????????? (????? 7) ?????????????????????????????????????? 10 ???? ?????????????????????????????????????????????????????????????????????????? 0.015 ??? 1.00 ????????????????????? ????????????????????????????? 6.86 ??? 9.66 ???????????????????? ?????????????????????????????????????????????????????????????????????????????????????????????????????? 80.28 ??? 100.09 ???????????????????????????? 0.46 ??? 4.33