Copper-Catalyzed Multicomponent Reactions toward Synthesis of 1,2,3-Triazoles

Abstract

In recent years, multicomponent reactions (MCRS) have been applied to the synthesis of natural products and commercial drugs. They can reduce the number of required reaction steps and being an efficient eco-friendly protocol. The synthesis of 2-(1,2,3-triazolyl)benzamide derivatives 4 was accomplished in a one-step process via copper-catalyzed reaction from 2-iodobenzamides, NaN3, and terminal alkynes. The domino process consisted of C(aryl)-N bond formation to generate aryl azide intermediate, followed by an azide-alkyne cycloaddition. The purification of aryl azide intermediate was not necessary in our protocol. In addition, the absence of external base was a solved key in the competitive reaction pathway.