Designed, Fabricated and Constructed Tissue Engineering Scaffolds Based on Mimic and Bio-Inspiration Appoach for Maxillofacial defect Treatment and Disease Evaluation

Abstract

Maxillofacial defect from trauma and diseases is the critical problems for many patients. Some defects need performance biomaterials for treatment and evaluation. Tissue engineering scaffolds is the attractive performance biomaterials which were selected to create, fabricate, and construct in this research. Four tissue engineering scaffolds based on mimic and bio-inspiration design were proposed for using in tissue defect treatment and disease evaluation. The first mimicked scaffold was created for using in soft tissue engineering in maxillofacial defect. The second mimicked pathogenic scaffold was used as ex-vivo biomaterials for osteoporosis evaluation. The third scaffold was created with the bio-inspiration for bone tissue engineering. The fourth scaffold incorporated with TiC coated carbon particles was designed to use for mineralization in bone healing. The results demonstrated that the first scaffold showed the suitable structure and biological performance which is fit for soft tissue engineering at maxillofacial defect. The second scaffold displayed the suitable structure and functionality which relate and fit to ex-vivo biomaterial for osteoporosis. The third scaffold showed the structural formation similar to structural organization during bone formation. This scaffold had the performance which could promote bone tissue engineering. The fourth scaffolds showed unique performance to enhance mineralization in bone healing. This research indicated that those scaffolds based on mimic and bio-inspiration design is promising to be the performance biomaterials for maxillofacial defect treatment and disease evaluation.