การพัฒนาเซนเซอร์ทางเคมีไฟฟ้าสำหรับการตรวจวัดโปรเมทาซีน

Abstract

This study used a simple pyrolysis method followed by mechanical ball-milling to create a nano-bimetallic platinum/nickel composite on multi-walled carbon nanotubes (nano-Pt/Ni@MWCNT) composite as an electrode material. Results showed that the nano-Pt/Ni particles could be anchored on the surface of the MWCNT, which was confirmed by multiple characterizations. The nanostructure of synthesized composite provides a large specific surface area to expose a large number of active sites and the resulting enhanced electrical conductivity ultimate improves the electrocatalytic activity towards promethazine (PMZ). Furthermore, a nano-Pt/Ni@MWCNT/GCE coupled flow-injection amperometric system was used to electrochemically determine PMZ. The proposed sensor also demonstrated potential in analysis in cases involving a large number of samples, which can be rapid analysis with high sample throughput of around 60 samples h−1. Linearity of response was shown from 0.10 to 100 µM and from 100 to1000 µM PMZ. The detection limit was 0.03 µM and limit of quantification 0.11 µM. The proposed method demonstrated excellent reproducibility (RSD = 1.02 %, n = 6), repeatability (RSD = 1.44 %, n = 25), operational stability (RSD = 2.02%, n=100), and interference tolerance. The viability of the nano-PtNi@MWCNT/GCE was demonstrated for the detection of PMZ in spiked saliva, urine and beverage samples, with recoveries from 91 ± 3 to 105±2 %.