การสังเคราะห์ ศึกษาโครงสร้าง ศึกษาคุณสมบัติทางกายภาพเชิงแสงของเออริเดียม (III) กับลิแกนด์ 3-methyl-2-phenyI pyridine และ bis (diphenylphosphino) methane และคุณสมบัติในการเป็นสารออกฤทธิ์ยับยั้งเซลล์มะเร็งเต้านม

Abstract

The Ir(3 m-ppy), (dppm)Cl complex in which 3m-ppy is 3-methyl-2-phenyl pyridine and dppm is bis(diphenylphosphino)methane, was prepared from the reaction between dimeric complex of Ir2(3 m-ppy), Cl, and dppm ligand in dichloromethane. The structure of the dimer precursor Ir2(3m-ppy), Cl, was characterized by 'H-NMR, FTIR, ESI-MS, and Elemental analysis. It was found that the dimer precursor Ir2(3m-ppy),Cl, was in accordance with the expected structure. The electrochemical property was investigated by cyclic voltammetry (CV) which indicated an irreversible oxidation peak of Ir(III)/Ir(IV) at +1.55 V, while an irreversible reduction peak of ligand moiety was recognized at the peak maxima of -2.25 V in acetonitrile. The structure of Ir(3 m-ppy), (dppm)C1 complex was investigated by 'H-NMR, FTIR, ESI-MS, elemental analysis, and single crystal X-ray diffraction technique. It was found that the synthesized substance was a distorted octahedral geometry. The electrochemical property was able to monitor irreversible peak of L(III)/(IV) at +1.2 V. The photophysical properties were investigated by UV-Vis absorption and luminescence spectroscopic techniques. The absorption band was observed in the range of 280-450 nm and emission band at the maximum wavelength (A) = 500 nm. The quenching reaction of Ir(3 m-ppy), (dppm)Cl complex was studied for metal ion detection when Hg, Fe, and Cu2*were added in DMSO solution, the emission intensity decreased at the same concentration of metal ions (1x10 M), the presence of Fe showed the highest inhibition of emission intensity. In addition, Ir(3m-ppy),(dppm)Cl complex also exhibited the growth inhibition of breast cancer cells; MCF-7, MDA-MB-231, and HCC1937 with the IC50 of 1.3 ± 0.1, 0.8 ± 0.1, and 0.9±0.1, μM respectively.