การพัฒนาเซนเซอร์ทางเคมีไฟฟ้าสำหรับการตรวจวัดไซบูทรามีนในผลิตภัณฑ์อาหารเสริม

Abstract

In this work, the electrochemical sensor for determination of sibutramine in dietary supplement and weight-loss products was developed using a new electrode material of sodium/phosphorus dual-doped carbon nanotubes (Na/P-CNTs), which was produced by a facile hydrothermal method. The Na/P-CNTs nanocomposite was characterized by SEM, EDX, FTIR, and Raman spectroscopy. Electrochemical properties of the nanocomposite have been characterized by CV and EIS. The introduced CNT with doping of Na and P atoms modified electrode was beneficial for the improvement of electro-catalytic activities and facilitation of electron transfer pathways, which could contribute to the effective oxidation of sibutramine. Under optimal conditions of AdSV measurement, the analytical characteristics of Na/P-CNTs electrode to detect sibutramine show a wide linear range from 0.025 to 10 mg kg-1 and 10-60.0 mg kg-1 and a low detection limit of 0.010 mg kg-1. Furthermore, the Na/P-CNTs electrode exhibited good repeatability, reproducibility, anti-interferent ability and short time analysis (120 s) of sibutramine. In addition, the proposed sensor was successfully applied for voltammetric sensing of sibutramine in weight-loss products samples with good recoveries from 91±3% to 102±1%. This Na/P-CNT nanocomposite could become a promising electrode material in the future for the monitoring of other electroactive species and other electrochemical applications as electrode modifying material provide excellent performance comparable to standard methods.