การศึกษาฤทธิ์บรรเทาอาการถอนของสารสกัดกระท่อมในโมเดลหนูทดลองที่ชักนำให้เสพติด 3,4 methylenedioxy methamphetamine

Abstract

3,4-methylenedioxy-methamphetamine (MDMA), commonly known as E in Thailand, which is a derivative of amphetamine, which is populary known and widely used. MDMA works by acting as a stimulant and hallucinogen that producing of pleasure, emotional, increase energy and body temperature. Long-term MDMA addiction can destruction of brain cells, impaired memory and anxiety. Few studies examine the long-lasting effect of behavioral phenotype associated with MDMA. This study aimed to investigate the effects of extracted from kratom (Mitragyna speciosa (Korth.) Havil) reduced of withdrawal symptoms in MDMA-induced mice model. Male Swiss albino ICR mice were randomly divided into 3 group: control group, MDMA treated group (MDMA) (10 mg/kg) and MDMA treated with Kratom (kratom+E). After 5 days mice were withdrawn with saline and fed distilled water in control and MDMA group. kratom+E group treated with 80 mg/kg kratom extracted for 5 days. Mice were divided 8 in each group. The experimental was approximately 3 weeks. Drug was administered intraperitoneally once a day at 9.00 a.m. Withdrawal symptoms were observed and anxiety-like behavioral tests were performed. The open field test (OFT) showed no significant difference between the groups, Tail suspension test (TST) and forced swimming test (FST) found that resulted in significantly increase immobility time in mice (p<0.05) and elevated plus maze were found that after taking kratom extract tends to increase open-arm duration, spontaneous memory test using y-maze that found kratom has significantly increased short-term effect (p<0.01). In conclusion, the kratom extracted might be useful to apply and alternative to alleviating the withdrawal symptoms associated with MDMA addiction.