Please use this identifier to cite or link to this item: http://kb.psu.ac.th/psukb/handle/2016/19361
Title: Stability of quinine dihydrochloride in commonly used intravenous solutions
Authors: Sanguan Lerkiatbundit
Faculty of Pharmaceutical Sciences (Clinical Pharmacy)
คณะเภสัชศาสตร์ ภาควิชาเภสัชกรรมคลินิก
Keywords: Quinine
Issue Date: 1992
Publisher: Prince of Songkla University
Abstract: The stability of quinine dihydrochloride at two concentrations, 1.2 and 3.6 mg/ml, in common intravenous solutions was studied. Admixtures of quinine in the following vehicles were prepared in glass containers: 5% dextrose in water, 5% dextrose in normal saline solution, 5% dextrose in half strength saline solution and normal saline solution. The solutions were kept under the fluorescent light at room temperature. Drug concentrations were monitored for 24 hours using stability-indicating high pressure liquid chromatographic method. More than 90 percent of the initial concentration of quinine remained in all solutions under the study condition and all samples remained clear and colourless over the entire 24 hr period. Admixtures containing quinine 1.2 and 3.6 mg/ml in four infusion solutions studied were stable for at least 24 hr and did not required protection from light during 24 hr period.
URI: http://kb.psu.ac.th/psukb/handle/2016/19361
Appears in Collections:560 Research

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